Tag Archives: 上海夜网

14Oct/19

Prime minister to announce legal framework for Indigenous people in speech

first_imgAPTN NewsPrime Minister Justin Trudeau is scheduled to make a speech in the House of Commons Wednesday about a so-called new legal framework regarding Indigenous people.The speech is scheduled for 3:15 p.m. in Ottawa.“I think it’s time we recognize that a rights-based approach to Indigenous issues and to a partnership with Indigenous people to reconciliation is what we have to do,” said Trudeau Wednesday morning.“We have a constitution that created a space for Indigenous rights, but over the past decades, we haven’t done a very good job of putting those rights at the forefront of all our decision-making and all our engagement with them.”Indigenous Services Minister Jane Philpott was asked to speak about the legal framework but declined.More to come.last_img read more

30Sep/19

No 6 Overall Draft Pick Barkevious Mingo Hospitalized With

No. 6 overall draft pick Cleveland Browns rookie linebacker Barkevious Mingo has been hospitalized after suffering a bruised lung.Mingo, who was drafted from Louisiana State University in the first round in April, was injured in the first half of Cleveland’s 24-6 victory over Detroit on Thursday.The initial diagnosis was that Mingo had a rib injury, but following the game he was taken to the hospital for further examination. Coach Rob Chudzinski said Mingo would be kept overnight.The details on how Mingo was hurt are unclear. The 6-foot-4-inch, 240-pound player jogged to the tunnel with a trainer for treatment after he was injured.And more bad news hit the Browns when running back Dion Lewis broke his leg and is likely done for the season. Cleveland also lost offensive guard Jason Pinkston, who suffered a severely sprained ankle. He left the stadium in a walking boot and on crutches. read more

28Sep/19

Back to back Billy Price becomes second Ohio State center in a

Billy Price and the Buckeyes prepare to take the field for warmups prior to the B1G Championship game against Wisconsin on Dec. 2 in Lucas Oil Stadium. Ohio State won 27-21. Credit: Jack Westerheide | Photo EditorBack to back.For the second year in a row, an Ohio State lineman was awarded the Rimington Trophy, which is given to the best center in the nation. One year after Pat Elflein won the award, redshirt senior Billy Price was voted to receive the trophy. He received the honor at the College Football Awards show Thursday night.Price beat finalists Alabama’s Bradley Bozeman and LSU’s Will Clapp for the trophy.The redshirt senior adds the trophy to his list of accolades, which includes the 2017 Big Ten offensive lineman of the year award. The Associated Press named Price a second-team All-American last season and he was named a first-team All-Big Ten honoree. Price was named a Rimington Trophy finalist on Monday and was named to the watch list in May. Both Price and Elflein switched from guard to center for their respective senior seasons. read more

18Sep/19

Rafael Benitez denies fight with Jamaal Lascelles

first_imgThe Newcastle United manager has said the player was absent during the weekend during an ankle problem and not because of an argumentNewcastle United coach Rafael Benitez has denied any argument with captain Jamaal Lascelles.The Spanish manager says the footballer’s absence from the match against Chelsea was because the player has an ankle problem.“The doctor is better than me, we’re waiting for results of a scan for Jamaal,” Benitez told the media as reported by Sportskeeda.“He came to support the team, I spoke to him before and after the game and three or four times this morning.”Tammy Abraham, ChelseaChelsea hat-trick hero Tammy Abraham hopes for more Andrew Smyth – September 14, 2019 Tammy Abraham hopes this season will be his big breakthrough at Chelsea after firing his first hat-trick for the club in Saturday’s 5-2 win at Wolves.“His partner is expecting a baby but everything is fine. I don’t know how long he’ll be out for,” he explained.MEDIA: Newcastle United boss Rafa Benítez has been speaking to the media ahead of Wednesday’s @Carabao_Cup clash against @NFFC. Here’s what he had to say… #NUFC— Newcastle United FC (@NUFC) August 28, 2018last_img read more

18Sep/19

Klopp and Neville rant takes another twist

first_imgGary Neville’s latest suggestion about Liverpool seem not to have gone down well with the German boss Jurgen Klopp following his comments.The United legend suggested that Liverpool’s best shot at delivering the first ever Premier League trophy would come if they didn’t try to juggle every competition this term.When asked about Neville’s recommendation at his Friday press conference, the Reds boss laughed it off and claimed he didn’t fully understand Neville’s logic.“Gary should come over and tell me exactly how that would work,” Klopp said. “You bring your kids in the Champions League? That would be funny!“I don’t want to be too critical because I don’t know exactly how he said it but sitting in an office and talking about football is completely different to doing the job, to be honest.Cristiano Ronaldo, Nemanja Vidic, Manchester UnitedVidic: “Ronaldo is the most professional footballer I’ve seen” Andrew Smyth – September 14, 2019 Nemanja Vidic opened up on how a 21-year-old Cristiano Ronaldo’s professionalism left him stunned at Manchester United.“What did he say about Manchester United in that case? The club he’s more interested in. Nothing?“I don’t know exactly what it means but to focus on one competition can only be if maybe you are already out of the competition nearly.“If it’s late in the season that you see you have a chance to do that or do this and all that stuff.“Last year, for example, we had no chance to focus on one competition because we had to qualify for the Champions League and I don’t think that even Gary Neville would have said: ‘Quarter-finals of the Champions League, let City win’.”last_img read more

18Sep/19

Robert Huth retires from football

first_imgFormer Leicester City defender Robert Huth has announced his retirement from football after reports linking him with a move to Derby County.While responding to claims that he’s set to join Frank Lampard’s Derby County on an 18-month deal, Huth also revealed that has retired from playing football.Three-time Premier League winner 🏆@robert_huth has announced his retirement from football.More: https://t.co/4jMeUvdmLO pic.twitter.com/Q3l66opxGO— Sky Sports Premier League (@SkySportsPL) January 11, 2019Harry Maguire, Manchester UnitedLiverpool legend Nicol slams Harry Maguire’s Man United form Andrew Smyth – September 14, 2019 Steve Nicol believes Harry Maguire has made some “horrendous mistakes” recently, and has failed to find his best form since joining Manchester United.According to Sky Sports, the 34-year-old replied to the Twitter report saying: “This literally couldn’t be less true,” Huth said. “I’ve retired! (I just haven’t done an interview and cried about it).”Huth had quite a successful career playing only in England, as he represented Chelsea, Middlesbrough, Stoke, and Leicester.The defender came up through the Youth system at Chelsea and won two Premier League titles at Stamford Bridge during Jose Mourinho’s first spell in charge.He made 42 appearances for Chelsea and scored no goals, and left in 2016 to join Middlesbrough.The German center back would later Stoke City after three years at the Riverside Stadium and was part of Leicester’s squad that won the Premier League title against all odds in 2016.last_img read more

14Sep/19

Monday Update Swan Lake Fire Remains Highly Active Community Meeting Wednesday

first_imgAshford: “The majority of the movement on the fire is away from the community of Sterling. It’s heading to the east as it moves to higher elevations in the Chugach National Forest.” The next community Meeting will be held on Wednesday, July 10, at 6:00pm, at the Cooper Landing Elementary School, 19030 Bean Creek Road, Cooper Landing. Jonathan Ashford with the State Division of Forestry: “The community of Cooper Landing has been really impacted by smoke from the fire. We’ve heard from folks that they have concerns and would like updated information on the fire.”  The weather pattern will continue hot and dry with high temperatures around 90-degrees through Monday. Later in the week, high temperatures are expected to decrease as clouds and relative humidity increase. Winds have been predominately out of the north but a change to a southerly direction is anticipated. For smoke forecasts from Alaska wildfires, visit UAFSMOKE at http://smoke.alaska.edu. The containment line north of the Homer Electric transmission line is holding well as small areas of interior vegetation burn, further increasing the depth of the fuel break created to protect the community of Sterling and the Sterling Highway. Facebook0TwitterEmailPrintFriendly分享Hot, dry weather is challenging fire personnel in all areas of the fire. The east flank continues to move upslope and into higher elevations along the mountain ridge line. The fire is estimated at 96,889 with 394 personnel assisting with the fire. Air quality monitoring stations have been set up near Cooper Landing and Seward. Real time reports are available 24-hours a day at http://tools.airfire.org and click on the Monitoring PM2.5. Crews are working to improve the Skyline Trail to create a fuel break along the southeast corner of the fire to prevent fire spread along the highway. Helicopters will continue to utilize water drops to cool areas producing heat north of Upper Jean Lake.last_img read more

03Sep/19

ERD to publish national human development report

first_imgSpeakers at a Consultation meeting on publishing of National Human Development Report organized by ERD on Sunday. Photo: CollectedThe government is planning to restart publication of National Human Development Report (NHDR) to facilitate policy dialogue and better understanding of development dynamics, says a press release.The NHDR was published in 1992 for the first time by the government but it did not continue later.The Economic Relations Division (ERD) will publish the report with the support of United Nations Development Programme (UNDP).The decision was taken at a meeting organised by the ERD at the meeting room of Executive Committee of National Economic Council (ECNEC) on Sunday.A total of 40 representatives of different ministries and private sector research organisations took part in the consultation meeting.Speaking at the meeting, Selim Jahan, director of UNDP Human Development Report Office in New York, said that the increase of GDP growth and infrastructural development alone cannot guarantee the human development.“Focus should be the improvement of living standard of the people,” he added.Discussants suggested forming an advisory council to guide the authors’ panel in choosing the themes and contents of the report.Chaired by ERD secretary Kazi Shofiqul Azam, the meeting was addressed by member of general economic division’s member Shamsul Alam, UNDP’s country director Sudipto Mukerjee, CPD’s research director Khondaker Golam Moazzem, and senior research fellow of Bangladesh Institute of Development Studies (BIDS) Nazneen Ahmed.last_img read more

02Sep/19

Sessions Orders Border Prosecutors To Adopt ZeroTolerance Policy On Immigration

first_imgBob Daemmrich for The Texas TribuneU.S. Attorney General Jeff Sessions speaks about carrying out President Donald Trump’s immigration priorities at the U.S. Attorney’s Office for the Western District of Texas in Austin on Friday, Oct. 20, 2017.U.S. Attorney General Jeff Sessions on Friday, April 6, ordered federal prosecutors on the southwest border to adopt a “zero tolerance” policy against anyone who enters or attempts to enter the country illegally, a mandate he said “supersedes” any prior directives.“To those who wish to challenge the Trump Administration’s commitment to public safety, national security, and the rule of law, I warn you: illegally entering this country will not be rewarded, but will instead be met with the full prosecutorial powers of the Department of Justice,” Sessions said in a statement. “To the Department’s prosecutors, I urge you: promoting and enforcing the rule of law is vital to protecting a nation, its borders, and its citizens.”The directive instructs all federal prosecutors on the southwest border to prosecute all Department of Homeland Security referrals for alleged violations of federal immigration illegal-entry laws. In a one-page memo sent to federal prosecutors on the southwest border, Sessions said the goal wasn’t merely developing more immigration cases, but instead an end to the “illegality in [the] immigration system.” He added that if the new policy requires more resources, the offices should identify and request those to the Department of Justice.The mandate comes the same week President Donald Trump has assailed Democrats for supporting what he said are “catch and release” policies where individuals apprehended by the Border Patrol are released while they await a court date. (The Washington Post later reported that “catch and release” actually flourished under the George W. Bush administration.)It’s unclear what the mandate will do to the current immigration-court case backlog, which was at more than 684,000 as of February, according to the Transactional Records Access Clearinghouse at Syracuse University. That figure includes more than 105,000 cases pending in Texas courts, higher than any state but California. The move is the latest in a busy week for the administration, which has also seen Trump sign a proclamation ordering the deployment of National Guard troops to the border until construction of his promised wall on the southwest border is complete. Sharelast_img read more

02Sep/19

Harris County To Get New Voting Machines By May 2021

first_img 00:00 /00:43 X Andrew Schneider/Houston Public MediaHarris County Clerk Diane Trautman, speaking at the International Association of Government Officials Conference Trade Show Sharecenter_img Harris County is set to replace its antiquated voting machines, which are based on 20-year-old technology. But the work won’t be done in time for the 2020 presidential election.The new voting infrastructure will cost $74 million, with the funding coming out of the 2020 budget. Speaking at a trade show on Tuesday, County Clerk Diane Trautman said it will take until March just to narrow down the selection of voting machines to the top two vendors. She expects to pick the supplier by July of next year.“Actually just to make 5,000 machines will take months,” Trautman said. “So to get them back, put them in the field, teach the election workers and the voters how to use them, you are looking at, our estimate is the May 2021 election before they can be used.”Trautman called for replacing the county’s voting machines as part of her election campaign in 2018.In the meantime, Trautman said her office is taking other steps to try to make voting easier and more convenient. This fall will mark the second time Harris County will use countywide voting centers. The centers allow voters to cast their ballots at any polling location on Election Day, rather than just the one in their assigned precinct. The Houston Endowment awarded the county $250,000 for a voter outreach and education campaign about the centers.“Additionally, we are adding up to six new early voting locations for the November election, including my alma mater, the University of Houston,” Trautman said. That will bring the total number of early voting locations in the county to 52.Andrew Schneider/Houston Public MediaA prospective voter tries out an Election Systems & Software voting machine at the International Association of Government Officials Conference Trade Show. To embed this piece of audio in your site, please use this code: Listenlast_img read more

31Aug/19

Host cellentry mode of African henipavirus could be its Achilles heel

first_img Citation: Host cell-entry mode of African henipavirus could be its Achilles heel (2015, April 14) retrieved 18 August 2019 from https://phys.org/news/2015-04-host-cell-entry-mode-african-henipavirus.html (Phys.org)—The recognition of a suite of African henipaviruses (HNVs), which are related to pathogenic Hendra and Nipah viruses, is a wake-up call to medical organizations worldwide. The initial symptoms of henipavirus infection—fever and headache followed by rapid-onset encephalitis—have likely resulted in misdiagnosis by medical workers as malaria-associated encephalitis, and fatalities from infection approach 90 percent. As a result of the symptomatic commonalities between henipaviruses and other paramyxoviruses, researchers are now reassessing the spread of HNVs. Crystal structure of GhV-G in complex with ephrinB2. The six-bladed β-propeller of GhV-G is shown as a rainbow ramped from blue (N terminus) to red (C terminus). The Greek-key fold of ephrinB2 is shown as a gray cartoon. Asparagine-linked N-acetylglucosamine moieties are shown as pink sticks. Credit: (c) PNAS 2015, doi:10.1073/pnas.1501690112 This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Mechanism found for development of protective HIV antibodies More information: “Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus.” PNAS 2015 ; published ahead of print March 30, 2015, DOI: 10.1073/pnas.1501690112AbstractThe discovery of African henipaviruses (HNVs) related to pathogenic Hendra virus (HeV) and Nipah virus (NiV) from Southeast Asia and Australia presents an open-ended health risk. Cell receptor use by emerging African HNVs at the stage of host-cell entry is a key parameter when considering the potential for spillover and infection of human populations. The attachment glycoprotein from a Ghanaian bat isolate (GhV-G) exhibits <30% sequence identity with Asiatic NiV-G/HeV-G. Here, through functional and structural analysis of GhV-G, we show how this African HNV targets the same human cell-surface receptor (ephrinB2) as the Asiatic HNVs. We first characterized this virus−receptor interaction crystallographically. Compared with extant HNV-G–ephrinB2 structures, there was significant structural variation in the six-bladed β-propeller scaffold of the GhV-G receptor-binding domain, but not the Greek key fold of the bound ephrinB2. Analysis revealed a surprisingly conserved mode of ephrinB2 interaction that reflects an ongoing evolutionary constraint among geographically distal and phylogenetically divergent HNVs to maintain the functionality of ephrinB2 recognition during virus–host entry. Interestingly, unlike NiV-G/HeV-G, we could not detect binding of GhV-G to ephrinB3. Comparative structure–function analysis further revealed several distinguishing features of HNV-G function: a secondary ephrinB2 interaction site that contributes to more efficient ephrinB2-mediated entry in NiV-G relative to GhV-G and cognate residues at the very C terminus of GhV-G (absent in Asiatic HNV-Gs) that are vital for efficient receptor-induced fusion, but not receptor binding per se. These data provide molecular-level details for evaluating the likelihood of African HNVs to spill over into human populations.center_img Explore further Journal information: Proceedings of the National Academy of Sciences © 2015 Phys.org Since the 1990s, more than 20 henipaviruses have been detected throughout Africa, Asia, Australia and Central America. The virus resides in populations of Old World fruit bats and its introduction to humans is believed to be through animal intermediaries such as pigs, or through the slaughter of the bats themselves for meat. HNVs are extremely pathogenic, and have been designated as high-priority agents that require handling under stringent biosafety conditions.Due to the potential for spillover from animal to human populations, researchers are focusing on the molecular-level structure of the viruses in order to determine their host-cell entry activities. A group of U.S.- and U.K.-based researchers have recently published a paper in the Proceedings of the National Academy of Sciences that studies a human cell surface receptor recognized by an emergent African hepinavirus strain called GhV, derived from a Ghanian fruit bat. They found that despite targeting a particular binding scaffold that exists across a range of HNVs, the molecular differences between these viruses prevented cross-reaction of antibodies, inhibiting development of a vaccination strategy.Currently the only African HNV for which envelope sequence information is available, GhV is related to other highly contagious HNVs, and the researchers find that it displays an HNV-G β-propeller binding scaffold similar to that in Asiatic HNVs. Despite structural differences, these structures are capable of of accommodating nearly identical primary ephrinB2-binding modes at the surfaces of host cells. The researchers note that bat and human cell-surface ephrinB2 sites are quite similar and likely maintain similar modes of binding, and that cross-infections are therefore likely.They write, “… the apparent structural plasticity and low level of sequence conservation on the HNV-G receptor-binding β-propeller scaffold are likely to prove an obstacle in the rational design of vaccines that produce broadly neutralizing antibodies to the ever-expanding spectrum of HNVs and HNLVs.”The virus-receptor interaction was confirmed via crystallography, and the researchers noted significant structural differences with previously documented HNV-G-ephrinB2 structures, but not in the key fold of the bound ephrinB2. They conclude that this conserved mode of ephrinB2 interaction represents an evolutionary constraint across divergent HNVs.Through structure-based phylogenic analysis, the researchers found that GhV-G and its cognate in Asiatic NiV likely evolved separately, after the viruses bifurcated from a common ephrin-binding HNV ancestor. They speculate that the ephrin-2 binding site represents a constraint of evolution that has conserved ephrinB2 binding by HNVs, a potential Achilles heel that could be exploited in vaccine research. The researchers introduced GhV to antibodies against NiV, finding that they did not cross-react with the GhV-G binding scaffold. Those antibodies also failed to neutralize CedV, a distantly related HNV. Despite a failure to find these cross-reactions, the researchers note that all of the studied HNVs mediate ephrinB2-dependent host-cell entry, and suggest that prime-boost vaccination is a possible strategy for eliciting broadly neutralizing antibodies that can target the ephrinB2-binding sites across a diverse HNVs.last_img read more

31Aug/19

Preprogramming materials to shape shift at a given time w video

first_img(Phys.org)—A team of researchers with the University of North Carolina at Chapel Hill and the University of Akron has devised a method to shape shift materials into a preconditioned state at a preprogrammed time. They have published a paper in the journal Nature Communications describing their materials and how they can be programmed and have created a video that shows the shape shifting in action. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Sequential ‘blooming’ of an artificial flower, which has been assembled from individually programed petals Supplementary Movie 4. Credit: Sheiko et al. Nature Communications Heat, light stimulate self-assembly: Researchers develop shape-changing ‘smart’ material Creating materials that can change shape under given conditions would be useful in a variety of applications, including space-based constructions, microstructures for delivering medications inside the human body or monitoring abilities. Up until now, however, such constructs have relied on an external stimulus to cause the change to occur, e.g. heat, light or even a change in pH level. In this new effort, the researchers have developed a material that can be caused to initiate shape shifting at a preprogrammed time.The team created their materials by making use of two different types of chemical bonds—dynamic and permanent—using hydrogel polymers that were similar to human cartilage. The dynamic bonds control the change in state while the permanent bonds control the final state of the material after it has shape shifted. The energy that is stored due to folding is what ultimately drives the transformation. Preprogramming is done by adjusting the parameters that define the bonds such as location, strength and number. The team reports that they can control the shape shifting to within hours, minutes or even seconds.The team also reports that they created many objects to test the materials. To demonstrate the effectiveness of their approach, they created a flower that blooms over time with different parts opening after others, just as occurs in nature. They filmed the action, speeded it up, and then posted a video of the results on YouTube. The team also notes that they believe such material could be used to deliver drugs in the body in a novel way—they would be transported to the site where they are needed and delivered when the material shape shifted, allowing the drug to be released. © 2016 Phys.orgcenter_img Journal information: Nature Communications Citation: Preprogramming materials to shape shift at a given time (w/ video) (2016, September 28) retrieved 18 August 2019 from https://phys.org/news/2016-09-preprogramming-materials-shift.html Explore further More information: Xiaobo Hu et al. Programming temporal shapeshifting, Nature Communications (2016). DOI: 10.1038/ncomms12919AbstractShapeshifting enables a wide range of engineering and biomedical applications, but until now transformations have required external triggers. This prerequisite limits viability in closed or inert systems and puts forward the challenge of developing materials with intrinsically encoded shape evolution. Herein we demonstrate programmable shape-memory materials that perform a sequence of encoded actuations under constant environment conditions without using an external trigger. We employ dual network hydrogels: in the first network, covalent crosslinks are introduced for elastic energy storage, and in the second one, temporary hydrogen-bonds regulate the energy release rate. Through strain-induced and time-dependent reorganization of the reversible hydrogen-bonds, this dual network allows for encoding both the rate and pathway of shape transformations on timescales from seconds to hours. This generic mechanism for programming trigger-free shapeshifting opens new ways to design autonomous actuators, drug-release systems and active implants.last_img read more

31Aug/19

Two BJP supporters arrested from Howrah

first_imgKolkata: Two BJP supporters were arrested on Wednesday from Howrah, for damaging state-run buses and intervention in police work on September 26, when the party had called a 12 hour bandh to protest against the killing of two students in Islampur in police firing.With the arrest of the two BJP supporters, the total number of arrests relating to bandh related issues in the district rose to 8.The BJP supporters had set fire to three state-run buses and caused extensive damage to 8 other buses on the day of the bandh.Acting on a tip-off, police raided the houses of the two BJP supporters on Wednesday afternoon and arrested them. They were produced before the court and have been remanded to police custody for three days.The arrested BJP workers had also stopped police from discharging their duties.On Brabourne Road, BJP supporters set fire to a state-run bus. Some buses were also damaged in North Bengal. In Howrah, BJP workers pelted stones at a taxi that was carrying a patient to SSKM Hospital. They forced the driver to stop the vehicle and forced the patient to get down.In Islampur also, the police arrested a local BJP leader for threatening the police and taking out a procession without police permission.last_img read more

31Aug/19

News of fatwa against Nusrat found to be fake

first_imgKolkata: The news of fatwa given by Darul Uloom to Nusrat Jahan for wearing bindi and marrying a non-Muslim, which is being circulated in national media for the past couple of days, has been found to be false.An investigation carried out by fact-checking website AltNews has proved that the news regarding Nusrat’s marriage is a fake one. Nusrat, the Trinamool MP from Basirhat who has recently married businessman Nikhil Jain, took her oath in Parliament in Bengali and touched the feet of the Speaker. Nusrat’s gesture was appreciated by social media and media alike. The controversy began after a national television channel telecast the statement of Asad Kashim of Darul Uloom, portraying him as an Ulema. He had allegedly criticised Nusrat’s gesture, her marrying a non-Muslim and wearing bindi. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataSome media channels subsequently began telecasting Asad’s statement as a fatwa. AltNews got hold of Asad, who told the reporter that the representatives of two national channels had asked him for his comment on the matter and he had expressed his views, which have nothing to do with a fatwa. He has also denied any connection with Darul Uloom. There is nothing on the fatwa in the official website of Darul Uloom either. When contacted by AltNews, a senior official of Darul categorically denied the issuance of any such fatwa against Nusrat.last_img read more

30Aug/19

Robert Scoble Tech Treps Should Be Crazy Passionate

first_imgJune 14, 2012 Growing a business sometimes requires thinking outside the box. Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Global Entrepreneur: What does an aspiring tech entrepreneur need to be successful?Scoble: Be passionate about your idea to the point of craziness. Unless you’re so passionate about your idea that you’re going to keep doing it until you die, you’re probably not going to develop to full potential.If you talk to venture capitalists, they look for a few things. One, does the entrepreneur have a team behind him or her that can deliver on the business plan? Adoption is another big thing. Is anyone using the product?For me, a tech startup needs to be in an interesting area, what I call “battlefields.” If you show me a Windows XP app, I don’t care if it’s the coolest thing you ever thought of. If you show me the app on an iPad, I’ll probably be more interested. The iPad is the future.Related: Mark Cuban: Outwork and Outlearn Your CompetitionEntrepreneur: What’s the future of social media and tech?Scoble: I think we’re at the beginning of a shift, moving from the conversation age to a more contextual age. Google Glasses, which we’re starting to see prototypes of, informs us what this contextual age means. If I’m walking down the street, they should be able to show me information that I need to know while walking. Not a movie, because I need to walk and navigate. If I start driving a car . . . they should show information about accidents or speed limits. It’s all about context.Entrepreneur: What inspires you professionally?Scoble: I love meeting people who see the world in a new way. Sitting down with Tony Hsieh at Zappos and understanding what customer service is all about. Or with Sergey Brin to find out that he’s working on these glasses and self-driving cars, getting a glimpse at how the world might shift because of what he’s doing at Google.Entrepreneur: How do you stay on top of your game?Scoble: I’m a social media fanatic. At my desk, I have three big screens in front of me on which I watch Twitter, Facebook, Google+, Gmail, Quora, Techmeme, Salesforce Chatter so I know what my co-workers are talking about — you name it. I sit there and it’s like the world comes to me.Related: Guy Kawasaki: No ‘Secret Sauce’ for Tech Success min read Robert Scoble’s finger is on the pulse of technology. He not only blogs about tech and publicly speaks about it, he follows almost 33,000 people and organizations on Twitter. He’s passionate about social media and emerging technologies — and the entrepreneurs behind them — to the point of obsession.After serving as a technical evangelist at Microsoft in the early 2000s and later as a vice president of a video podcasting network called PodTech, the popular tech blogger works as a managing director of Rackspace, a cloud-based website hosting company in San Antonio, Texas. We sat down with Scoble to chat about tech startups and the trends that are guiding the industry.What follows is an edited version of our exchange: Register Now »last_img read more

09Aug/19

Local officials attend SOS with Rep Johnson

first_img16Jan Local officials attend SOS with Rep. Johnson State Rep. Joel Johnson, R-Clare, welcomed Craig Pollington of Osceola County, Carolyn Curtin of Osceola County, Adam Kroczaleski of Arenac County, and Rev. Kathy and Joe Groff of Clare County to Gov. Rick Snyder’s State of the State address in the House chamber on Wednesday evening.  Johnson said the priorities the governor laid out in his third speech are important for making Michigan better and the one the 97th District lawmaker was putting at the top of his list was career development for the next generation.“I think we’ve missed the boat somewhat with our high school students in particular, where we’ve said each student has to be prepared for a university education,” Johnson said. “I really feel that we need to make sure those who have an interest in a vocational skill have an opportunity to learn those skills without being penalized and then are able to join the workforce with a good-paying job.” Categories: Johnson News,Johnson Photos,Newslast_img read more

26Jul/19

Facebook Snaps Up FaceSwapping App Creator Masquerade

first_img Brought to you by Reuters Facebook Snaps Up Face-Swapping App Creator Masquerade Facebook Inc. is acquiring Masquerade Technologies Inc., creator of the popular face-swapping app MSQRD, as part of efforts by the world’s largest social network operator to build its video services.Wednesday’s deal comes nearly three years after the Wall Street Journal reported that photo and video messaging app Snapchat had rejected an offer from Facebook.Masquerade, which announced the deal on its website, did not disclose financial details.The deal is more a piece of Facebook’s bigger effort to innovate into video, Monness, Crespi, Hardt, & Co. Inc. analyst James Cakmak said.It is unlikely that Facebook would use Masquerade to significantly draw away Snapchat users, he said.While Snapchat has features such as bulging eyes, Masquerade allows users to add special effects including animal masks and snow to their photos and video.Masquerade, backed by Yuri Gurski and Gagarin Capital, said founders Eugene Nevgen, Sergey Gonchar and Eugene Zatepyakin will join Facebook.The app will continue as a standalone product, Masquerade said.(Reporting by Yashaswini Swamynathan in Bengaluru; Editing by Sriraj Kalluvila)  Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. 2 min read Image credit: Kim Lachance Shandrow | Instagram Fireside Chat | July 25: Three Surprising Ways to Build Your Brand March 10, 2016center_img Add to Queue Reuters Next Article –shares Facebook Enroll Now for $5last_img read more

19Jul/19

Promising technology could improve detection diagnosis of fatal ovarian cancer

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Nov 14 2018Ovarian cancer claims the lives of more than 14,000 in the U.S. each year, ranking fifth among cancer deaths in women. A multidisciplinary team at Washington University in St. Louis has found an innovative way to use sound and light, or photoacoustic, imaging to diagnose ovarian tumors, which may lead to a promising new diagnostic imaging technique to improve current standard of care for patients with ovarian cancer.Quing Zhu, professor of biomedical engineering in the School of Engineering & Applied Science and of radiology, and a team of physicians and researchers at Washington University School of Medicine in St. Louis recently conducted a pilot study using co-registered photoacoustic tomography with ultrasound to evaluate ovarian tumors on 16 patients at the School of Medicine and Barnes-Jewish Hospital. Results of the study were recently published online in Radiology.”When ovarian cancer is detected at an early, localized stage — stage 1 or 2 — the five-year survival rate after surgery and chemotherapy is 70 to 90 percent, compared with 20 percent or less when it is diagnosed at later stages, 3 or 4,” said Zhu, a pioneer of combining ultrasound and near-infrared imaging modalities for cancer diagnosis and treatment assessment. “Clearly, early detection is critical, yet due the lack of effective screening tools only 20-25 percent of ovarian cancers are diagnosed early. If detected in later stages, the survival rate is very low.”In their approach, researchers use transvaginal ultrasound to obtain information about ovarian tumors, but ultrasound lacks accuracy in diagnosis of ovarian masses, Zhu said. Photoacoustic tomography, however, gives researchers a very detailed look at the tumor’s vasculature, or tumor angiogenesis, and blood oxygen saturation (sO2) by lighting up the tumor’s vasculature bed and allowing for more accurate diagnoses of ovarian masses seen by ultrasound.Both tumor angiogenesis and tumor sO2 are related to tumor growth, metabolism and therapeutic response. The Washington University team is the only team using co-registered photoacoustic imaging and ultrasound to diagnose ovarian cancer.In the pilot study, Zhu and her team created a sheath with optical fibers that wrap around a standard transvaginal ultrasound probe. The optical fibers are connected to a laser. Once the probe is inside the patient, Zhu turns the laser on, which shines through the vaginal muscle wall. With photoacoustic tomography, the light from the laser propagates, gets absorbed by the tumor and generates sound waves, revealing information about the tumor angiogenesis and sO2 inside the ultrasound-visible ovaries. A normal ovary contains a lot of collagen, Zhu said, but an ovary with invasive cancers has extensive blood vessels and lower sO2.The team used two biomarkers to characterize the ovaries: relative total hemoglobin concentration (rHbT), which is directly related to tumor angiogenesis, and mean oxygen saturation (sO2). In this pilot study, the team found that the rHbT was 1.9 times higher for invasive epithelial cancerous ovaries, which make up 90 percent of ovarian cancers, than for normal ovaries. The mean oxygen saturation of invasive epithelial cancers was 9.1 percent lower than normal and benign ovaries. All five invasive epithelial cancerous ovaries, including two stage 1 and 2 cancers, showed extensive rHbT distribution and lower sO2.Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskUsing machine learning algorithm to accurately diagnose breast cancerNew protein target for deadly ovarian cancer”Physicians are very excited about this because it might bring significant change into current clinical practice,” Zhu said. “It is very valuable to detect and diagnose ovarian cancers at early stages. It is also important to provide information and assurance to patients that there is no worry about their ovaries, instead of removing a patient’s ovaries. This technology can also be valuable to monitor high-risk patients who have increased risk of ovarian and breast cancers due to their genetic mutations. The current standard of care for these women is performing risk reduction surgeries to remove their ovaries at some point, which affects their quality of life and causes other health problems.””We are very fortunate to participate in this research endeavor headed by Dr. Zhu,” said Cary Siegel, MD, professor of radiology and chief of gastrointestinal/genitourinary radiology at the School of Medicine. “This photoacoustic imaging study has great potential to better identify ovarian cancers and may play a valuable role in screening high-risk patients and triaging patients for follow-up imaging or surgical excision.”Zhu credits her physician collaborators, including Siegel; Matthew Powell, MD, associate professor and chief of the Division of Gynecologic Oncology; Ian Hagemann, MD, PhD, assistant professor of pathology & immunology; David Mutch, MD, the Ira C. and Judith Gall Professor of Obstetrics and Gynecology; the radiology team and the entire gynecology group, as well as her doctoral students Sreyankar Nandy, Atahar Mostafa and Eghbal Amidi, who worked on instrumentation, control software and data processing.”I really appreciated this as a group effort to bring the study to this point,” Zhu said. “This technology may provide a means to improve early ovarian cancer detection, help avoid surgery in most patients with a normal or benign ovary, substantially reduce medical costs, and improve women’s quality of life. We look forward to bringing this study to the next level.”These initial results will need to be validated with more patients, Zhu said, and the team is applying for funding to conduct a large clinical trial.Source: https://source.wustl.edu/2018/11/hopeful-technology-could-change-detection-diagnosis-of-deadly-ovarian-cancer/last_img read more

18Jul/19

Free health check up ignored by more than half of the population

first_imgDoctor measuring blood pressure with sphygmomanometer. Image Credit: Kurhan / Shutterstock The free health tests included screening for dementia, heart diseases, kidney ailments and type 2 diabetes. The NHS said that over 15 million people were eligible to take the tests while only a minority took them. Since 2013, only 7.15 million individuals have taken these tests.  Experts have added that the tests would be just 20 minutes long but help detect many conditions and save lives. A GP or a nurse would check the body weight and height and measure the blood pressure as part of the test. Irregular heartbeats, risks for strokes can all be identified with the test. Strokes and risks of vascular dementias could also be assessed say experts.They explain that dementia and Alzheimer’s kills thousands each year in England and Wales. These tests could help diagnose the conditions early. Alistair Burns, national clinical director for dementia at NHS England says, “The start of a new year is exactly the right time to commit to taking a simple, free and potentially life-saving step towards a healthier life.”Related StoriesHealthy lifestyle lowers dementia risk despite genetic predispositionResearch team to create new technology for tackling concussionArtificial intelligence can help accurately predict acute kidney injury in burn patientsThese health check-ups are offered to all individuals aged between 40 and 74 with no pre-existing health conditions. They are provided every five years. Laura Phipps, head of communications at Alzheimer’s Research UK says, “There is good evidence to suggest that what’s good for the heart is also good for the brain, but while 77% people believe they can reduce their risk of heart disease, only 34% of people know they can reduce their risk of dementia… Research shows that midlife is a crucial time to take action that will help maintain a healthy brain into later life. With dementia now the UK’s leading cause of death, we must encourage everyone to take positive steps to maintain good brain health throughout life and into older age.”These five yearly checks are part of the NHS’ effort to diagnose dementia early among the population of England. The organization is trying to ensure that least two thirds of the people with dementia are diagnosed and treated early.The programme at the Public Health England is led by Jamie Waterall who said, “The NHS health check looks at the top causes of premature death and ill health but more importantly supports people to take action of reducing their risk of preventable conditions such as dementia and heart disease.”The test is followed by advice on improving health and lifestyle that includes having a healthy balanced diet, regular exercise, quitting smoking, taking medications to lower blood pressure and cholesterol, losing excess body weight etc. By Dr. Ananya Mandal, MDJan 1 2019The NHS England provided a free health check up to the population over forty years of age and has noted that more than half of them did not take the health check-ups that could detect and treat dementias and other conditions.last_img read more

18Jul/19

Researchers create 3D vascularized proximal tubule model to study renal reabsorption

first_imgImmunofluorescence staining of a 3D bioprinted vascularized proximal tubule with a proximal tubule epithelial marker stained in green in the proximal tubule channel and a vascular endothelial marker stained in red in the adjacent vascular channel. The magnified cross-section illustrates that the two different cell types form luminal perfusable structures in their respective channels. Credit: Wyss Institute at Harvard University Reviewed by James Ives, M.Psych. (Editor)Mar 5 2019Every day our kidneys tackle the daunting task of continuously cleaning our blood to prevent waste, salt and excess fluid from building up inside our bodies. To achieve this, the kidneys’ approximately one million filtration units (glomeruli) first remove both waste products and precious nutrients from the blood stream, then specialized structures known as the proximal tubules reabsorb the “good” molecules returning them to our bloodstream. While the reabsorptive functions of the proximal tubule can be compromised by drugs, chemicals, or genetic and blood-borne diseases, our understanding of how these effects occur is still limited. To enable the study of renal reabsorption outside the human body, Wyss Institute Core Faculty member Jennifer Lewis, Sc.D., and her team working within the Wyss Institute’s 3D Organ Engineering Initiative that she co-leads, and in collaboration with the Roche Innovation Center Basel in Switzerland, created a 3D vascularized proximal tubule model in which independently perfusable tubules and blood vessels are printed adjacent to one another within an engineered extracellular matrix. This work builds upon a continuously perfused 3D proximal tubule model reported earlier by the team that still was lacking a functional blood vessel compartment. Using their next-generation device, the team has measured the transport of glucose from the proximal tubule to the blood vessels, along with the effects of hyperglycemia, a condition associated with diabetes in patients. Their study is published in the Proceedings of the National Academy of Sciences (PNAS).Lewis is also the Hansjörg Wyss Professor of Biologically Inspired Engineering at Harvard John A. Paulson School of Engineering and Applied Science (SEAS), the Jianmin Yu Professor of Arts and Sciences and a member of the Harvard Stem Cell Institute.”We construct these living renal devices in a few days and they can remain stable and functional for months,” said first-author Neil Lin, Ph.D., who is a Roche Fellow and Postdoctoral Fellow on Lewis’ team. “Importantly, these 3D vascularized proximal tubules exhibit the desired epithelial and endothelial cell morphologies and luminal architectures, as well as the expression and correct localization of key structural and transport proteins, and factors that allow the tubular and vascular compartments to communicate with each other.”Related StoriesAn active brain and body associated with reduced risk of dementiaNanoparticles used to deliver CRISPR gene editing tools into the cellResearchers identify gene mutations linked to leukemia in children with Down’s syndromeAs a first step towards testing drugs and modeling diseases, the team induced “hyperglycemia”, a high-glucose condition typical of diabetes and a known risk factor for vascular disease, in their model by circulating a four-fold higher than normal glucose concentration through the proximal tubule compartment. “We found that high levels of glucose transported to endothelial cells in the vascular compartment caused cell damage,” said Kimberly Homan, Ph.D., a co-author on the study and Research Associate in Lewis’ group at the Wyss Institute and SEAS. “By circulating a drug through the tubule that specifically inhibits a major glucose transporter in proximal tubule epithelial cells, we prevented those harmful changes from happening to the endothelial cells in the adjacent vessels.”The team’s immediate focus is to further scale up these models for use in pharmaceutical applications. “Our system could enable the screening of focused drug libraries for renal toxicity and thus help reduce animal experiments,” said Annie Moisan, Ph.D., a co-author and industry collaborator on the study, and Principal Scientist at Roche Innovation Center Basel. “I am thrilled by the continued efforts from us and others to increase the physiological relevance of such models, for example by incorporating patient-specific and diseased cells, since personalized efficacy and safety are the ultimate goals of predicting clinical responses to drugs.””Our new 3D kidney model is an exciting advance as it more fully recapitulates the proximal tubule segments found in native kidney tissue,” said Lewis. “Beyond its immediate applications for drug screening and disease modeling, we are also exploring whether these living devices can be used to augment kidney dialysis.” Currently, life-saving dialysis machines filter blood, but they are unable to retrieve precious nutrients and other species from the filtrate that the body needs for many of its functions, which can cause specific deficiencies and complications down the line. Lewis and her colleagues believe that 3D bioprinted vascularized tubules may lead to improved renal replacement therapies.”This study presents a significant step forward in human kidney engineering that enables human disease and drug-related studies to be carried out over extended periods of time in vitro. It also represents a major step forward for the Wyss Institute’s 3D Organ Engineering Initiative, which aims to generate functional organ replacements with enhanced functionalities for patients in need.” said Wyss Institute Founding Director Donald Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at HMS and the Vascular Biology Program at Boston Children’s Hospital, as well as Professor of Bioengineering at SEAS.Source: https://wyss.harvard.edu/renal-reabsorption-in-living-devices/last_img read more